FIELD: chemistry.
SUBSTANCE: invention relates to chemistry of natural compounds, specifically to enhanced synthesis of ecdysteroids - insect molting hormones. The invention describes a single-step method for synthesis of 2-dehydro-3-epi-20-hydroxyecdysone 1 during ozonation of 20-hydroxyecdysone (2) in a pyridine solution at 0-25°C for 10-20 minutes. Ecdysteroid 1 obtained that way was extracted in crystalline form with output of 83% in terms of reacted 20-hydroxyecdysone (2). Melting point and specific angle of rotation were further determined for the 20-hydroxyecdysone. The structure of the obtained product was confirmed through a combination of 1D and 2D NMR 1H and 13C spectra.
EFFECT: method ensures high output of ecdysteroid via a single-step process.
1 cl, 3 ex
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