METHOD OF OBTAINING 2,3,5,7,8-PENTAHYDROXY-6-ETHYL-1,4-NAPHTOQUINONE Russian patent published in 2009 - IPC C07C50/32 C07C46/10 

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining 2,3,5,7,8-pentahydroxy-6-ethyl-1,4-naphtoquinone (equinochrome A), which is used as active substance of medications of "Histochrome" series and for production of active additives "Timarin", "Chitochrome-C", "Zolotoy Rog". As raw material, preserved sand dollars, which are separated from preservative by decantation, are used, formed preservative is filtered and applied onto chromatographic column filled with dehydrated chitosan in OH form, then chitosan with adsorbed in it equinochrome A is washed with 96% ethyl alcohol, and out of preserved sand dollars are covered with 96% ethyl alcohol with ratio raw material : extragent 1: (1.0-1.2) with addition of inorganic acid with ratio ethyl alcohol : acid 100 : (1.0-1.5), extraction being carried out during 20-24 hours at room temperature until raw material is fully exhausted; then obtained extract is passed through the same column filled with dehydrated chitosan in OH^- form, further chitosan, with adsorbed on it equinochrome A, is washed successively with 30-40% water solution of ethyl alcohol and 96% ethyl alcohol, then equinochrome A from column is eluted with 96% ethyl alcohol with addition of hydrochloric acid (pH 2-3), obtained acid eluate is neutralised with baking soda to pH 4-5, filtered and evaporated until full solvent removal, further, dry residue is dissolved in chloroform or acetone, filtered and evaporated again, then residue is crystallised from ethyl alcohol and dried.

EFFECT: obtaining equinochrome A with high output.

4 dwg, 2 ex