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2 412 712

(13)

(51)

IPC

A61K31/727(2006-01-01)

A61K31/198(2006-01-01)

A61K31/192(2006-01-01)

A61K47/36(2006-01-01)

A61P7/02(2006-01-01)

A61K35/00(2006-01-01)

A61K35/04(2006-01-01)

C08B37/10(2006-01-01)

(21) (22)

Application

2009124824/15, 2009-06-29

(24)

Start date

2009-06-29

(22)

Actual filing date

2009-06-29

(45)

Published

2011-02-27

(72)

Inventor

Tolstikova Tat'Jana GenrikhovnaSorokina Irina Vasil'EvnaZhukova Natal'Ja Anatol'EvnaBaev Dmitrij SergeevichPonedel'Kina Irina Jur'EvnaLukina Elena SergeevnaKhajbrakhmanova Ehl'Vira AzamatovnaOdinokov Viktor NikolaevichDzhemilev Usein Memetovich

(73)

Holder

Uchrezhdenie Rossijskoj Akademii Nauk Institut Neftekhimii I Kataliza Ran

ANTI-INFLAMMATORY MEDICATION WITH ANTICOAGULANT, ANTITUMOUR AND ANTIMETASTETIC ACTIVITY Russian patent published in 2011 - IPC A61K31/727 A61K31/198 A61K31/192 A61K47/36 A61P7/02 A61K35/00 A61K35/04 C08B37/10

Abstract RU 2412712 C1

FIELD: medicine.

SUBSTANCE: claimed is application of conjugate of heparin with lysine and ibuprofen of formula as anti-inflammatory medication with anticoagulant, antitumour and antimetastatic activity. Conjugate of heparin with lysine and ibuprofen, where R=So₃H/Ac (30:70).

EFFECT: conjugate possesses anti-inflammatory activity, which is 1,4 times higher than ibuprofen activity, anticoagulant activity is comparable with pharmacopeia heparin, its antitumour activity being comparable with that of doxorubicin, cyclophosphane, vincristine, prednisolone with demonstration of antimetastatic activity.

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RU 2 412 712 C1

Authors

Tolstikova Tat'Jana Genrikhovna

Sorokina Irina Vasil'Evna

Zhukova Natal'Ja Anatol'Evna

Baev Dmitrij Sergeevich

Ponedel'Kina Irina Jur'Evna

Lukina Elena Sergeevna

Khajbrakhmanova Ehl'Vira Azamatovna

Odinokov Viktor Nikolaevich

Dzhemilev Usein Memetovich

Dates

2011-02-27—Published

2009-06-29—Filed