CRYSTALLINE POLYMORPHOUS FORM OF THROMBIN RECEPTOR ANTAGONIST BISULFATE Russian patent published in 2009 - IPC C07D405/06 A61K31/44 A61P7/02 A61P9/00 A61P35/00 

Abstract RU 2355689 C9

FIELD: chemistry.

SUBSTANCE: invention concerns novel compound of crystalline polymorphous bisulfate form with antagonistic effect on thrombin receptors, displaying x-ray refraction in powder, almost identical to picture in Figure 1, or displaying differential scanning calorimetry diagram almost identical to picture in Figure 3, and presented by compound 2 formula: Compound 2. Additionally invention concerns method of obtaining compound 2.

EFFECT: claimed pharmaceutical composition including polymorphous bisulfate form and at least one solvent or carrier, and application of polymorphous form of compound 2 in treatment of various physiological disorders, such as thrombosis.

16 cl, 3 dwg, 3 tbl, 1 ex

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RU 2 355 689 C9

Authors

Tiruvengadam Tiruvettipuram K.

Vu Venksue

Vang Tao

Chiu Dzhon S.

Bogdanovich-Knipp S'Juzan

Pavlovski Anastasija

Grinli Uilliam Dzh.

Graziano Majkl P.

Kosoglou Tehddi

Chintala Madkhu

Chakalamannil Samuehl'

Dates

2009-05-20Published

2005-01-07Filed