THIENOPYRAZOLES Russian patent published in 2009 - IPC C07D495/04 A61K31/4162 A61K31/4188 

FIELD: chemistry.

SUBSTANCE: description is given of thienopyrazol of formula I its pharmaceutically acceptable salts or esters, in which X represents N or C-R⁷; X¹ represents N or C-R¹; R¹, R², R³, R⁴, R⁵ and R⁶ are independently chosen from a group which contains hydrogen, possibly substituted acyl, alkyl, alkoxy group, acylaminogroup, alkoxyalkyl, (Y¹)(Y²)NC(=O)-, alkoxycarbonyl, aryl, halogen, carboxy group; or R⁵ and R⁶ together with two carbon atoms with a double bond, with they are bonded, form a benzene ring; R⁷ is a hydrogen atom, halogen or alkyl; and Y¹ and Y² are independently a hydrogen atom, alkyl, aryl or heteroaryl, or Y¹ and Y² together with a nitrogen atom, with which they are bonded, form a heteroaryl group or heterocycloalkyl group. The invention also relates to pharmaceutical compositions, containing these compounds. Thienopyrazoles can be used for treating diseases, which can be affected by protein kinase inhibition, particularly, interleukin-2-induced tyrosine kinase.

EFFECT: wider field of application of the compounds.

14 cl, 1 tbl, 98 ex