PARENTERAL PREPARATION AND METHOD FOR MAKING THEREOF Russian patent published in 2009 - IPC A61K47/00 A61K31/00 A61K9/08 A61J3/00 A61P25/00 A61P9/00 A61P35/00 A61P31/00 A61P31/12 

FIELD: medicine.

SUBSTANCE: pharmaceutical composition for making a parenteral preparation contains a pharmaceutical agent, a water-soluble polymer, a nonpolymeric additive and a solvent. The water-soluble polymer is chosen from the group: dextran, gelatin, 2-hydroxyethy starch, poly(N-vinylpyrrolidone), human blood serum albumin or their mixture. The nonpolymeric additive is chosen from the group: (C₁₀-C₁₈)acyl-sorbite, oligooxyethylene(C₁₀-C₁₈)acyl-sorbite, (C₁₀-C₁₈)alkyl oligooxyethylene glycol ester. The solvent represents mixed water and ethanol, or dimethyl sulphoxide, or N-methyl-2-pyrrolidone, or 2-pyrrolidone. The pharmaceutical agent, said water-soluble polymer, nonpolymeric additive and residual solvent are found in the preparation as a noncovalent complex.

EFFECT: improved bioavailability of the pharmaceutical agents and therapeutic dose decline.

2 cl, 1 dwg, 1 tbl, 1 ex