FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to a compound of formula 
, where R1 is selected from H and CH3; R2 is selected from H and linear C1-C4-alkyl; X stands for OH or a residue of formula NHR3, where R3 is selected from H, OH, C1-C5-alkyl, C3-C6-cycloalkyl, C1-C5-alkoxy; branched or non-branched C1-C6-alkyl, substituted with carboxy-(COOH) group; a residue of formula SO2R4, where R4 stands for C1-C2-alkyl, C3-C6-cycloalkyl, C1-C3-halogenalkyl; Y stands for heretoatom, selected from S, O and N; Z stands for the residue, selected from halogen, linear or branched C1-C4-alkyl, hydroxy, amino, C1-C4-acylamino, halogen-C1-C3-alkyl, linear or branched C1-C8-alkanesulfonamide, and pharmaceutically acceptable salts of the said compound. The invention also relates to a method of obtaining formula (I) compounds. The compounds are applied for prevention and treatment of damage to tissues as a component of a pharmaceutical composition. The claimed invention deals with application of compounds in treatment of such diseases as transient cerebral ischemia, bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and lesions, caused by ischemia and reperfusion.
EFFECT: (R,S)-2-arylpropionic acids and their respective compounds, useful for prevention and treatment of damage to tissues, caused by enhanced recruiting of polymorphonuclear neutrophils (PMN-leukocytes) on regions of inflammation.
11 cl, 2 tbl, 46 ex
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