DERIVATIVES OF 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDEAS LIGANDS OF RECEPTOR CANNABINOIDS Russian patent published in 2008 - IPC C07D249/10 C07D401/04 C07D401/12 A61K31/41 A61P25/18 

FIELD: chemistry.

SUBSTANCE: here, described are new derivatives of 1H-1,2,4-triazole-3-carbozamide of the general formula (I) , wherein R is phenyl, possibly replaced by 1-2 halogen atoms, R₁ is phenyl possibly replaced by 1-2 halogen atoms or trifluotomethyl group, or pyridile radical; R₂ represents a hydrogen atom; R₃ - C_1-6-alkyl, C_2-8-alcoxy, C_3-8-cycloalkyl, possibly replaced with C_1-3-zalkyl or ethynil, C_2-8-bicycloalkyl, C_4-8-alkenil, C_3-8-trifluoroalkyl or C_2-8-fluoroalkyl group or C_3-8-cycloalkyl, group NR₄R₅, where R₄ and R₅ together with nitrogen atom to which they are coupled, form a monocyclic or bicyclic heterocyclic fragment with 5-8 ring atoms, the heterocyclic group of the above fragment contains one or two heteroatoms, selected from the group N and O, possibly replaced with C_1-3-alkyl or R₂ and R₃ together with nitrogen atom to which they are coupled form 1,4'-bipyperidine radical, their pharmaceutically acceptable salts.

EFFECT: pharmaceutical composition is used for treatment of disturbances involving neurotransmission of cannabinoids.

5 cl, 43 ex, 1 tbl