METHOD FOR PREDICTION OF CLINICAL COURSE OF INFECTIOUS ENCEPHALITIS IN CHILDREN Russian patent published in 2024 - IPC G01N33/68 A61B5/01 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to infectious diseases, neurology and paediatrics, and can be used for prediction of infectious encephalitis course in children. Clinical and laboratory examination is carried out, in which: body temperature for 5 days, type 2 and 3 oligoclonal IgG synthesis in cerebrospinal fluid (CSF) and blood serum, level in CSF interferon-gamma (IFN-γ), pg/ml, and interleukin-4 (IL-4), pg/ml. Method includes calculating the ratio of IFN-γ/IL-4. Obtained values are used to calculate linear discriminant functions by formulas: LDF 1= 4.05+7.7⋅X1+4.8⋅X2+2.45⋅X3+0.18⋅X4, LDF 2= 11.8+3.5⋅X1+19.1⋅X2+16.6⋅X3+5.9⋅ 4, where X1 is body temperature in first 5 days from the moment of development of neurological symptoms, and at a body temperature of 37.1°C and higher - X1 = 1, and at body temperature 37°C and below, X1 = 0; X2 is type 2 synthesis of oligoclonal IgG in CSF and blood serum, and if the patient has type 2 synthesis of oligoclonal IgG - X2 = 1, and in the absence of type 2 synthesis of oligoclonal IgG - X2 = 0; X3 is type 3 of IgG synthesis in CSF and blood serum, and in presence of 3 type of oligoclonal IgG synthesis - X3 = 1, and in absence of 3 type of oligoclonal IgG synthesis - X3 = 0; X4 is coefficient of ratio of IFN-γ/ IL-4 in CSF, and with coefficient >1 - X4 = 1, and with coefficient ≤1 - X4 = 0. Values of indicators are compared, and LDF1 > LDF2 predict acute course, and LDF1 < LDF2, chronic infectious encephalitis.

EFFECT: method provides the possibility of increasing the accuracy of the prediction of the clinical course of infectious encephalitis in children, which enables the well-timed differentiated correction of the therapy and improve the outcomes of the neuroinfectious process by assessing the clinical and laboratory parameters: body temperature for 5 days, the presence of type 2 or 3 oligoclonal IgG synthesis in the CSF and blood, the level of IFN-γ and IL-4 in CSF.

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