INACTIVATED BIVALENT CATTLE VIRUS DIARRHOEA AND ADENOVIRUS INFECTION VACCINE AND METHOD FOR PREVENTION OF CATTLE VIRUS DIARRHOEA AND ADENOVIRUS INFECTION Russian patent published in 2009 - IPC A61K39/295 A61P31/12 

FIELD: veterinary science.

SUBSTANCE: group of inventions concerns veterinary virology and biotechnology. Said vaccine contains antigen of adenovirus serotype type one B-10, inactivant, concentrated adjuvant PEG-6000 in final concentration 10%. In addition, the vaccine contains virus antigen of virus diarrhoea "Origon", concentrated 8-9% PEG-6000 dissolved in 0.5-0.6 M NaCl. As an inactivant, the vaccine contains afficinal formalin, and as an adjuvant - afficinal "ГОА". The components of the vaccine are related as follows (vol. %): antigen of adenovirus serotype type one B-10 with infectious titre 6-7 lg "ТЦД"₅₀/ml, 5 times concentrated PEG-6000 dissolved in 0.5-0.6 M NaCl - 30-37, virus antigen of virus diarrhoea of strain "Origon" with infectious titre 7-8 lg "ТЦД"₅₀/ml, 5 times concentrated PEG-6000 dissolved in 0.5-0.6 M NaCl - 30-37, formalin 40% - 0.5-0.8, "ГОА" afficinal 6.0% - the rest. The vaccine is introduced to calves intramuscularly twice every 13-16 days in a dose 1.0 ml.

EFFECT: vaccine has high preventive activity.

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