N-ACYLATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AS LIGANDS OF PPAR-RECEPTORS, ACTIVATED BY PEROXISOME PROLIFERATOR Russian patent published in 2009 - IPC C07D413/12 C07D207/16 C07D417/12 C07D403/12 A61K31/401 A61K31/422 A61K31/427 A61K31/4196 A61P35/00 A61P3/10 A61P17/00 A61P19/02 A61P25/28 A61P31/12 A61P3/06 A61P9/10 A61P9/12 

Abstract RU 2374241 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds of formula (I), their R and S isomers; or a mixture of R and S isomers; or pharmaceutically acceptable salts. Disclosed compounds can be used as a medicinal agent with agonist properties towards PPAR. In formula (I) and L represents (II) or (III); R1, R2, R3, Ya, R4a, R", Yb, R4b are hydrogen; R and R' are independently hydrogen, C1-C4alkoxy; n equals 0, 1 or 2; m equals 0, 1 or 2; X1 is a -Z-(CH2)P-Q-W group; X2 is -CH2-, -C(CH3)2-, -O- or -S-.

EFFECT: invention relates to a pharmaceutical composition, which contains the disclosed compound, to use of the pharmaceutical composition as a medicinal agent, to use of the disclosed compound in making the pharmaceutical composition.

13 cl, 35 ex

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RU 2 374 241 C2

Authors

Ksander Gehri Majkl

Vedananda Talattani Ralalage

Dates

2009-11-27Published

2004-05-19Filed