LIGAND WITH WIDE RANGE OF SIMULTANEOUS RECEPTOR ACTIVITY, PHARMACEUTICAL COMPOSITION, METHOD OF PREPARING SAID COMPOSITION AND MEDICINAL AGENT Russian patent published in 2009 - IPC C07D471/02 A61K31/437 A61P25/28 

FIELD: chemistry.

SUBSTANCE: present invention relates to ligand with a wide range of simultaneous receptor activity towards adrenergic α_1A, α_1B , α_1D, α_1A, α_2A, β₂, dopamine D₁, D₂₁, D_2S, D₃, serotonin 5-HT_1B, 5-HT_2A, 5-HT2B, 5-HT_2C, 5-HT₆, 5- HT₇, sigma α₁, α₂ receptors, to calcium and sodium channels, monoamine transporters [norepinephrine (NET) and dopamine (DAT)], which is 3-methyl-9-benzyl-1,2,3,4-tetrahydrocarbonyl naphthalene-1,5-disulphonate of formula 1:

. The invention also relates to a pharmaceutical composition, which has a medicinal origin, which is a ligand of formula 1 with the given range of simultaneous receptor activity for preventing and/or treating diseases of the central nervous system, pathogenesis of which is related to GPCR receptors, ion channels and monoamine transporters, method of preparing said composition, and to medicinal agents.

EFFECT: range of simultaneous activity towards said receptors increases capacity and effectiveness of using the said ligand.

10 cl, 10 dwg, 7 ex