FIELD: medicine.
SUBSTANCE: genetically modified cell of yeast is produced either by introduction of an alien gene, or by variation in expression of its own gene. To compensate effect of these genes in cell, expression of certain genes is varied in ascending (up-regulation) or descending (down-regulation) manner. Using micromatrices (microarrays) of DNA, they identify compensatory expressing genes. Compensatory genes are affected, which results in reduction or cessation of expression of up-regulated genes or improved expression of down-regulated genes. As a result, a phenotype occurs in cell, which expresses as inhibitor of its growth.
EFFECT: invention makes it possible to produce organism for screening of biologically active substances, which affect genes, expression variation of which does not show in phenotype manner.
9 cl, 1 dwg, 4 tbl, 2 ex
