STEREOISOMERICALLY ENRICHED 3-AMINOCARBONYL BICYCLOHEPETENE PYRIMIDINE DIAMINES AND USE THEREOF Russian patent published in 2011 - IPC C07D239/48 C07D403/12 C07D413/12 A61K31/506 A61P35/04 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds with structural formula (I) in form of (2-exo-3-exo)cis-racemate or diastereomer with structural formula (1a) and pharmaceutically acceptable salts thereof, having antiproliferative action and aurora-kinase inhibiting properties. In formulae (I) and (1a), each R¹ is hydrogen; each R² is independently selected from a group comprising a hydrogen atom, lower alkyl and ; each R³ is independently selected from a group comprising a hydrogen atom, lower alkyl and ; each R⁴ is independently selected from a group comprising a hydrogen atom and lower alkyl; R⁵ is a halogen atom.

EFFECT: invention also relates to a pharmaceutical composition, methods of inhibiting proliferation of tumour cells, activity of aurora-kinase, an aurora-kinase mediated process, a method of treating an aurora-kinase mediated disease and use of said compounds to prepare a medicinal agent.

43 cl, 4 dwg, 4 tbl, 14 ex