FIELD: chemistry.
SUBSTANCE: present invention relates to a method of producing novel 4-oxo-4H-chromene derivatives containing a vinyl and an enamine group, having general structural formula: 
1-5. 1 R-Me X=H Y=CO2Me; 2 R=Me X=Y=CO2Me; 3 R=Bn X=H Y=COMe; 4 R=Bn X=H Y=CO2Me; 5 R=Bn X=Y=CO2Me, which involves mixing 1.0 mmol of 1,2,3,4-tetrahydro-10H-chromeno[3,2-c]pyridin-10-one of general structural formula: 
, where R assumes the given value, with 1.2 mmol of methyl propiolate, acetyl acetylene or dimethyl dicarboxylate and stirred at room temperature for 1 hour until the precipitate of the starting compound disappears. The solvent is then stripped to dryness and the remaining oil is triturated in a mixture of ethyl acetate and hexane until crystallisation thereof.
EFFECT: obtaining novel compounds which can be used as compounds which exhibit cytotoxic activity and also have antisclerotic activity.
1 cl, 5 ex
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