METHOD OF CARDIAC HYSTIOCYTES PROLIFERATION Russian patent published in 2010 - IPC C12N15/10 C12N15/09 A61K31/7088 A61K48/00 

FIELD: medicine.

SUBSTANCE: cardiac hystiocytes are proliferated by inducing of cyclin and CDK expression in cardiac hystiocytes and by inhibiting function or activity of protein of Cip/Kip family or by inhibiting production of protein of Cip/Kip family. There is described expression vector that contains a cyclin gene, a cyclin-dependent kinase gene and one or several agents chosen from the group consisting of a gene coding the factor which inhibits production, function or activity of protein of Cip/Kip family and nucleic acid sequence which inhibits production of protein of Cip/Kip family. There is disclosed pharmaceutical composition containing said vector, and applied for treatment of cardiac diseases. There is offered cardiac hystiocyte produced by the declared method. There is presented method of treating a cardiac disease that implies injection of the disclosed pharmaceutical composition.

EFFECT: regeneration and recovery of cardiac hystiocytes.

31 cl, 13 dwg, 1 tbl, 6 ex