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2 392 315

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IPC

C12N5/00(2006-01-01)

C12N5/71(2010-01-01)

(21) (22)

Application

2006114832/13, 2004-10-04

(24)

Start date

2004-10-04

(22)

Actual filing date

2004-10-04

(45)

Published

2010-06-20

(72)

Inventor

Fukuda KejitiJuasa SinsukeOkano KhidejukiSimazaki TakujaKosimizu UitiTanaka TomofumiSugimura Kejdziro

(73)

Holder

Fukuda Kejiti

METHOD OF STEM CELLS DIFFERENTIATION INTO MIOCARDIAL CELLS INDUCTION Russian patent published in 2010 - IPC C12N5/00 C12N5/71

Abstract RU 2392315 C2

FIELD: medicine.

SUBSTANCE: pluripotent stem cells are cultivated to induce their differentiation in the presence of compound, inhibiting signalling pathway mediated by BMP, in aggregational cultivation in suspension or in combined cultivation with feeder cells. Compound, inhibiting signalling pathway mediated by BMP, is added before differentiation or at first stages of cultivation within induction of differentiation, or in the moment of both mentioned method combining.

EFFECT: improved effectivity of myocardiocyte differentiation from stem cells and possibility to obtain purer culture of differentiated cells.

10 cl, 13 dwg, 8 ex

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RU 2 392 315 C2

Authors

Fukuda Kejiti

Juasa Sinsuke

Okano Khidejuki

Simazaki Takuja

Kosimizu Uiti

Tanaka Tomofumi

Sugimura Kejdziro

Dates

2010-06-20—Published

2004-10-04—Filed