FIELD: medicine.
SUBSTANCE: there is offered molecule of nucleic acid inducing CEA immune response, containing a nucleotide sequence that codes a fused protein on a basis of carcinoembryonal antigen (CEA) or its functional version fused with a subunit B of thermolabile enterotoxin E coli. There are described versions thereof, as well as the related purified protein. There is disclosed an expression vector containing said molecule of nucleic acid, and a host-cell containing specified vector. There are described adenoviral vaccinal vector for inducing the immune response and a vaccinal plasmid on the basis of the specified molecule.
EFFECT: application of the invention allows to inducing the immune response in a mammal which is stronger, than that induced with natural CEA that can find application in medicine for cancer treatment.
20 cl, 62 dwg, 20 ex
| Title | Year | Author | Number |
|---|---|---|---|
| FUSED PROTEIN OF TELOMERASE REVERSE TRANSCRIPTASE, NUCLEOTIDES CODING THEM, AND USING THEM | 2007 |
|
RU2473691C2 |
| NUCLEIC ACID SYNTHETIC MOLECULE (VERSIONS), MAMMAL CELL EXPRESSION VECTOR, MAMMAL HOST CELL AND METHOD OF EXPRESSING ANTIGEN PROTEIN OF HUMAN EPIDERMAL GROWTH FACTOR-2 (HER2/neu) OR SHORTENED FORM THEREOF | 2004 |
|
RU2397249C2 |
| IMMUNOGENS FOR VACCINATION AGAINST HIV | 2013 |
|
RU2648791C2 |
| NUCLEOTIDE SEQUENCE EXPRESSING ANCHOR PROTEIN OF EXOSOMES FOR USE AS VACCINE | 2017 |
|
RU2761642C2 |
| VACCINE COMPOSITION | 2014 |
|
RU2684211C2 |
| COMPOSITION FOR TREATING HEPATITIS B VIRUS INFECTIONS | 2010 |
|
RU2555346C2 |
| INFLUENZA VIRUS NUCLEOPROTEIN BASED VACCINES | 2014 |
|
RU2662667C2 |
| EXPRESSION VECTOR ENCODING CORONAVIRUS-LIKE PARTICLE | 2004 |
|
RU2383621C2 |
| MODIFIED SUPERCOILED PROTEINS WITH IMPROVED PROPERTIES | 2013 |
|
RU2677799C2 |
| IMMUNOGENS FOR VACCINATION AGAINST HIV | 2013 |
|
RU2721274C2 |
