COMPOUNDS AND COMPOSITIONS AS TRO MIMETICS Russian patent published in 2010 - IPC C07D209/18 C07D235/18 A61K31/404 A61K31/4164 

FIELD: chemistry.

SUBSTANCE: invention concerns novel compounds of the formula I , where: n equals 0 or 1; Z denotes N, CR₈, where R₈ denotes H, C₁-C₆alkyl; R₁ R₂, R₄ and R₅ independently denote H, halogen, OH, -XNR₉R₁₀, where X denotes a chemical bond, and R₉ and R₁₀ denote H; R₃ denotes - NR₁₁S(O)₂R₁₂, -NR₁₁C(O)R₁₂, -C(O)OR₁₁ -NR₁₁R₁₂, S(O)₂NR₁₁R₁₂ and - C(O)NR₁₁R₁₂, where R₁₁ and R₁₂ independently denote H, C₁-C₆alkyl; R₇ denotes hydrogen, C₁-C₆alkyl; R₇ denotes phenyl substituted with 1 or 2 groups independently selected from fluorine and C₁-C₆alkyl, and pharmaceutically acceptable salts thereof.

EFFECT: compounds exhibit TRO mimetics activity, which enables preparation of medicinal agents from them for increasing level of thrombocytes in the blood of an animal.

9 cl, 2 dwg, 15 ex