FIELD: medicine, pharmaceutics.
SUBSTANCE: described are water-soluble mono-PEGylated derivatives of tetrapyrrole of formulas (1A) or (2), (values of radicals Y,B,R1,R4-R6 are given in invention formula), pharmaceutical composition, containing them, method of obtaining compound (2), including interaction of corresponding tetrapyrrole of general formula (7) with aminopolyethyleneglycol of formula H-Y, containing functionalised end fragment.
EFFECT: application of novel compounds as photosensibiliser in photodynamic therapy.
5 cl, 2 tbl, 8 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD OF PREPARING WATER-SOLUBLE CHLORINES | 1998 |
|
RU2144538C1 |
PHOTOSENSIBILIZERS BASED ON (BACTERIO)CHLOROPHYLL FOR TREATMENT OF EYE DISEASES AND DISORDERS | 2012 |
|
RU2632439C2 |
WATER-SOLUBLE ANION-CONTAINING BACTERIOCHLOROPHYLL DERIVATIVES OF AND THEIR APPLICATION | 2003 |
|
RU2353624C2 |
CATIONIC BACTERIOCHLOROPHYLL DERIVATIVES AND USE THEREOF | 2005 |
|
RU2397172C2 |
TRANSESTERIFICATION METHOD FOR PRODUCTION OF SYNTHETIC CHLOROPHYLL OR BACTERIOCHLOROPHYLL DERIVATIVES | 2000 |
|
RU2250905C2 |
WATER-SOLUBLE ANALOGUES CC-1065 AND THEIR CONJUGATES | 2007 |
|
RU2489423C2 |
NOVEL CC-1065 ANALOGUES AND THEIR CONJUGATES | 2009 |
|
RU2562232C2 |
METHOD OF CHLORINE e6 PRODUCTION | 2006 |
|
RU2330037C1 |
NEW CC-1065 ANALOGS AND THEIR CONJUGATES | 2009 |
|
RU2628069C2 |
9A-AZALIDE FRAGMENTS OF MACROLIDE ANTIBIOTICS OF AZALIDE CLASS, METHOD OF THEIR SYNTHESIS AND INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS | 1995 |
|
RU2130936C1 |
Authors
Dates
2010-02-27—Published
2004-03-19—Filed