WATER-SOLUBLE MONO-PEGYLATED TETRAPYRROLE DERIVATIVES FOR PHOTODYNAMIC THERAPY AND METHOD OF OBTAINING THEM Russian patent published in 2010 - IPC C07D487/22 A61K31/40 A61P35/00

Abstract RU 2382787 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: described are water-soluble mono-PEGylated derivatives of tetrapyrrole of formulas (1A) or (2), (values of radicals Y,B,R¹,R⁴-R⁶are given in invention formula), pharmaceutical composition, containing them, method of obtaining compound (2), including interaction of corresponding tetrapyrrole of general formula (7) with aminopolyethyleneglycol of formula H-Y, containing functionalised end fragment.

EFFECT: application of novel compounds as photosensibiliser in photodynamic therapy.

5 cl, 2 tbl, 8 ex

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RU 2 382 787 C2

Authors

Nifant'Ev Nikolaj Ehduardovich

Jashunskij Dmitrij Vladimirovich

Dates

2010-02-27—Published

2004-03-19—Filed