METHOD OF PRODUCING CHONDROITIN-6-SULPHATE FROM UMBILICAL CORDS OF NEWLY BORN BABIES Russian patent published in 2010 - IPC A61K35/44 A61K31/737 

Abstract RU 2383351 C2

FIELD: chemistry.

SUBSTANCE: mixture of chondroitin-6-sulphate and dermatan sulphate extracted from umbilical cords is oxidised with 2,2,6,6-tetramethylpiperidine-1-oxyl-NaClO-NaBr at pH 10.2 and temperature 0-5°C for 1 hour with subsequent precipitation of oxidation products with three ethanol objects and their separation on a chromatographic column with DEAE-cellulose using eluent in form of aqueous solutions of NaCl with increasing concentration 0.2→0.6 M in increment of 0.05.

EFFECT: obtaining pure chondroitin-6-sulphate; the rest of the products are hybrid polysaccharides consisting of chondroitin-6-sulphate and dermatan sulphate oxidised on the primary groups.

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Authors

Ponedel'Kina Irina Jur'Evna

Khajbrakhmanova Ehl'Vira Azamatovna

Lukina Elena Sergeevna

Odinokov Viktor Nikolaevich

Dzhemilev Usein Memetovich

Dates

2010-03-10Published

2008-02-20Filed