BENZO[d] ISOXAZOLE-3 DAAO INHIBITORS Russian patent published in 2010 - IPC C07D261/20 A61K31/423 A61P25/18 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula IA and their pharmaceutically acceptable salts. Claimed compounds have inhibitory effect on DAAO. In formula IA , A denotes hydrogen; Z denotes O; R¹ is selected from a hydrogen atom, hydroxy or methoxy; R² is selected from a hydrogen atom, F, Cl, hydroxy, methoxy and methyl; or R¹ is selected from a hydrogen atom, F, hydroxy and methoxy; and R² is selected from a hydrogen atom, Cl, hydroxy, methoxy and methyl; R³ is selected from C₁-C₆alkyl, hydroxy, methoxy, halogen, cyano, CH₂-CH₂-phenyl and OCH₂-phenyl; R^4a is selected from C₁-C₆alkyl, hydroxy, methoxy and halogen. The invention also relates to use of compounds in which R^3a denotes hydrogen, C₁-C₆alkyl, hydroxy, methoxy, halogen, cyano, CH₂-CH₂-phenyl, O-CH₂-phenyl, NH-CO-O-CH₂-phenyl, R^4a denotes H, C₁-C₆alkyl, hydroxy, methoxy, halogen, NH-CO-O-CH₂-phenyl, for making a medicinal agent.

EFFECT: wider field of use of the compounds.

14 cl, 4 tbl, 8 ex