SUBSTITUTED NAPHTHYRIDINE AND QUINOLINE COMPOUNDS AS MAO INHIBITORS Russian patent published in 2018 - IPC C07D215/20 C07D401/12 C07D471/04 C07D215/22 C07D215/54 A61K31/4375 A61K31/47 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, specifically a heterocyclic compound of formula (I), where n is 1 or 2; Y is CH or N; R¹ is pyridine substituted with -CF₃, or phenyl substituted only in the meta and para positions by one, two or three members R^a; each R^a is independently selected from the group consisting of halogen, -C_1-4alkyl, -CF₃, -NO₂ and -OC_1-4alkyl; R² is -C(R^b)₂R^c or -CO-R^d; each R^b is independently selected from the group consisting of -H and -C_1-3alkyl; R^c is selected from the group consisting of -F, -NH₂, -OH, -OC_1-3alkyl, -CH₂OH, -CN, -CO₂-C_1-4alkyl, -CO-NHR^e and -C(CH₃)₂OH; R^d is selected from the group consisting of -CH₃, -OC_1-4alkyl, -NHR^e and -NHCH₂CH₂N(R^e)_2; each R^e independently represents -H or -CH₃; R³ is selected from the group consisting of -H and -CH₃. Invention also relates to particular compounds and a pharmaceutical composition based on a compound of formula (I).

EFFECT: technical result: obtaining a novel heterocyclic compound useful for the treatment of a subject suffering from a disease, disorder or medical condition mediated by one or more monoamine oxidase (MAO) enzymes.

21 cl, 87 ex