METHOD FOR PREDICTION OF CHANGING FUNCTIONAL CLASS OF DISEASE IN PATIENTS WITH CHRONIC CARDIAC FAILURE Russian patent published in 2010 - IPC G01N33/84 G01N33/68 A61B8/02 A61B5/402 

FIELD: medicine.

SUBSTANCE: prediction of increasing the functional class of chronic cardiac failure (FC CCF) within the next year is ensured by determination of serum magnesium in blood serum (mmol/l) (XI), potassium of blood serum (mmol/l) (X2) and encephalic natriuretic peptide (pg/ml) (X3), observed diastolic dysfunction of left ventricle (LV) (1 - shown by cardiac ultrasound; 0 - not shown) (X4), high-grade ventricular premature beats (1 - shown by cardiac electrocardiogram; 0 - not shown) (X5) and cardiac fibrillation (1 - shown by cardiac ultrasound; 0 - not shown) (X6). The probability is calculated by formula Prob (event)=exp(eta)/(1+exp(eta)), where Prob (event) is probability of CCF progression, eta=-0.332674+2.12648*X1+6.34589*X2-0.00574387*X3+3.38776*X4=1-0.574371*X4+2-3.01702*X5=0; if Prob (event) is equal to 0, increasing the functional class is not expected; if Prob (event) is equal to 1, increasing the functional class by one unit is observed.

EFFECT: application of the method allows improving effectiveness of prediction of chronic cardiac failure progression.

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