FIELD: medicine; cardiology; oncology and rehabilitation.
SUBSTANCE: invention can be used to assess the risk of progression of chronic heart failure (CHF) in patients with breast cancer during 24 months of observation after chemotherapy with an anthracycline drug — doxorubicin. In the blood serum of patients immediately after the diagnosis of CHF, the content of matrix metalloproteinase-9 (MMP-9) is determined by enzyme immunoassay. If the MMP-9 level is 21.25 ng/ml or more, a high risk of doxorubicin-induced CHF progression is predicted.
EFFECT: opportunity to improve the quality of prediction of chronic heart failure induced by doxorubicin in patients with breast cancer during 24 months of observation by quantifying the expression of MMP-9 in blood serum after the diagnosis of CHF.
1 cl, 1 dwg, 4 tbl, 2 ex
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