CYCLOPROPYLPIPERIDINE GLYCINE TRANSPORTER INHIBITORS Russian patent published in 2010 - IPC C07D211/68 C07D211/80 C07D213/02 A61K31/445 A61P25/18 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula I , where R² is selected from a group consisting of (1) phenyl, which is substituted with R^2a, R^2b and R^2c, (2) furanyl, (3) C_3-6 cycloalkyl; R^2a, R^2b and R^2c are independently selected from a group consisting of (1) hydrogen, (2) halogen, (3) C_1-6 alkyl, which is unsubstituted or substituted with (a) 1-6 halogen atoms, (4) -NR¹⁰R¹¹, where R¹⁰ and R¹¹ are hydrogen; R³ is C_1-6 alkyl or C_3-6 cycloalkyl, which is independently unsubstituted or substituted with 1-6 halogen atoms; R⁴ and R⁵ are hydrogen and m equals zero, R² is directly bonded to a carbonyl; and to pharmaceutically acceptable salts thereof. The invention also pertains to compounds which are selected from the group, as well as a pharmaceutical composition.

EFFECT: obtaining novel biologically active compounds which are active as glycine transporter GlyT1 inhibitors.

10 cl, 14 ex, 1 tbl