TETRALINE AND INDANE DERIVATIVES AND USE THEREOF Russian patent published in 2010 - IPC C07D295/08 A61K31/495 A61K31/40 A61K31/451 A61P25/00 

Abstract RU 2389723 C2

FIELD: chemistry.

SUBSTANCE: invention relates to new compounds of formula (I) their pharmaceutically acceptable salts , where: m equals 0; p assumes values from 1 to 2; q equals 2; Ar is a possibly substituted phenyl, where the substitute is a halogen; R2 is ; each of n and r is independently equal to 1 or 2; X is -NR3 when n equals 2, or X is -CHNR4R5 when n equals 1 or 2, where each of R3, R4 and R5 is independently hydrogen or methyl. The invention also relates to a pharmaceutical composition based on these compounds having selective affinity to 5-HT receptors.

EFFECT: obtaining new compounds and a pharmaceutical composition based on the said compounds which can be used in medicine to treat diseased conditions of the central nervous system and gastrointestinal tract disorders.

16 cl, 1 tbl, 4 ex

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RU 2 389 723 C2

Authors

Kharris Iii Ral'F N'Ju

Krauss Nensi Ehlizabet

Kress Dzhejms M.

Repke Devid Brjus

Stabler Rassell Stefen

Dates

2010-05-20Published

2005-12-12Filed