CHROMAN DERIVATIVES AND APPLICATIONS THEREOF IN TREATING CNS DISORDERS Russian patent published in 2010 - IPC C07D405/04 C07D405/12 C07D311/68 A61K31/353 A61P25/00 A61P1/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new chroman derivatives of formula I: , or to their pharmaceutically acceptable salts where m has a value of 0; p has a value of 2; q has a value of 2; Ar represents phenyl optionally substituted with halogen atom; R² represents ; X represents -NR⁹-; n has a value of 2 or 3; each R³, R⁴, R⁵ and R⁶ independently represents hydrogen or C_1-12alkyl; each R⁷ and R⁸ independently represents either hydrogen, or C_1-12-alkyl, or R⁷ and R⁸ together with nitrogen whereto attached, can form 4-6-members ring, or one of R⁷ and R⁸ and one of R⁵ and R⁶ together with atoms whereto attached can form 4-6-members ring; and R⁹ represents hydrogen or C_1-12-alkyl, or when R⁷ represents hydrogen or methyl, R⁹ together with R⁸ and atoms whereto attached can form 6-members ring.

EFFECT: preparation of chroman new derivatives and the pharmaceutical composition containing compounds of formula (I).

22 cl, 1 tbl, 5 ex