FIELD: chemistry; biochemistry.
SUBSTANCE: invention relates to molecular biology and biotechnology. Proposed are fragments of double-chain RNA with length of 22 nucleotides which contain trinucleotide projecting 3'-ends consisting of nucleotide chains of the following sequence: 5'-AAAN1N2N3N4N5N6N7GCCUGACACUUU/A-3' 5'-GUGUCAGGCN14N13N12N11N10N9N8UUUUUU/A-3', where N1-N7 are complementary to N8-N14, respectively, having antiproliferative and interferon-inducing activity.
EFFECT: obtaining compounds which can be used for making dosage forms of preparations used for treating viral diseases.
5 dwg 2 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MULTIPARAMETRIC DIAGNOSTIC TEST SYSTEM FOR QUANTITATIVE DETERMINATION OF MRNA LEVEL OF HUMAN RIG-1, IFIT-1, IFIH-1 GENES | 2021 |
|
RU2782428C1 |
| ANTIVIRAL COMPOSITION FOR PROTECTING PLANTS BASED ON POLY(A):POLY(U) | 2020 |
|
RU2768752C1 |
| NUCLEIC ACID HAVING ACTIVITY OF SHORT INTERFERING RNA, VECTOR CONTAINING THIS NUCLEIC ACID COUPLED OPERABLY WITH SEQUENCES OF TRANSCRIPTION REGULATION, AND METHOD OF THEIR APPLICATION FOR INHIBITION OF CELL PROLIFERATION OF HUMAN PANCREATIC ADENOCARCINOMA | 2013 |
|
RU2532842C1 |
| INDUCTION OF APOPTOSIS IN TUMOUR CELLS, EXPRESSING TOLL-LIKE RECEPTOR | 2005 |
|
RU2401661C9 |
| POLYPEPTIDE WITH ANTIVIRAL ACTIVITY, ITS PRODUCTION AND USE | 2004 |
|
RU2372356C2 |
| HOMOGENOUS PREPARATIONS OF IL-28 AND IL-29 | 2004 |
|
RU2518324C2 |
| TREATMENT OF CNS DISORDERS | 2007 |
|
RU2426544C2 |
| METHOD OF OBTAINING RECOMBINANT VESICULAR STOMATITIS VIRUS | 2022 |
|
RU2807751C1 |
| METHOD FOR INCREASING RNA EXPRESSION IN CELL | 2018 |
|
RU2784654C2 |
| RECOMBINANT PLASMID pFastBAC-B17R DNA CONTAINING COWPOX VIRUS GENOME FRAGMENT CODING ALPHA/BETA-INTERFERON BINDING PROTEIN AND BvB17RG BACULOVIRUS STRAIN PRODUCING SOLUBLE ALPHA/BETA-INTERFERON BINDING PROTEIN OF COWPOX VIRUS | 2009 |
|
RU2405824C1 |
