DOSAGE FORM PROTECTED FROM UNINTENDED USE AND CONTAINING (1R, 2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYLPROPYL)PHENOL Russian patent published in 2010 - IPC A61K9/22 A61K31/137 

FIELD: medicine, pharmaceutics.

SUBSTANCE: declared invention refers to chemical-pharmaceutical industry, and concerns a oral dosage form protected from unintended use with controlled release (1R, 2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol taken a day which contains specified active substance and/or one or more its pharmaceutically acceptable salts (A), at least one synthetic or natural polymer (C), an adjuvant delaying release of the active substance, other optional physiologically compatible adjuvants (B) exhibiting fracture strength at least 500 H. Besides such dosage can contain one of the listed ingredients preventing its unintended use (a) - (f): (a) at least one substance stimulate nasal or pharyngeal cavity, (b) at least one viscosity increasing agent, (c) at least one the active substance antagonist potentially being an object of its misuse, (d) at least one emetic, (e) at least one staining agent as an aversive agent, (f) at least one bitter substance.

EFFECT: development of the oral dosage form protected from unintended use with controlled release (1R, 2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol.

31 cl, 1 ex, 2 tbl, 1 dwg