EXTENDED RELEASE DURABLE DOSAGE FORMS Russian patent published in 2010 - IPC A61K9/22 A61K9/14 A61K9/52 A61K47/30 A61K47/34 A61K31/00 A61J3/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: dosage form contains a physiologically active substance (A), with the exception of tramadol hydrochloride and oxycodone hydrochloride, optionally one or more physiologically compatible pharmaceutical aids (B), synthetic or natural polymer (C) and optionally natural, semisynthetic or synthetic wax (D). Polymer (C) is chosen from the group including polyalkylene oxide, polyethylene, polypropylene, polyvinylchloride, polycarbonate, polystyrene, polyacrylate, their copolymers and mixtures. The dosage form according to the invention, exhibits breaking strength at least 400 H and under the physiologic conditions after 5 h, release maximum 99% of the physiologically active substance (A).

EFFECT: dosage form is mechanically stabilised; it reduces overdose risk invoked by the abuse and inadequate application, particularly chewing, grinding and pestling.

30 cl, 7 dwg, 17ex