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2 394 838

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IPC

C07K14/00(2006-01-01)

C07K5/06(2006-01-01)

A61K38/05(2006-01-01)

A61K38/16(2006-01-01)

A61K31/40(2006-01-01)

A61P31/12(2006-01-01)

A61P31/22(2006-01-01)

(21) (22)

Application

2008127281/04, 2008-07-08

(24)

Start date

2008-07-08

(22)

Actual filing date

2008-07-08

(45)

Published

2010-07-20

(72)

Inventor

Galegov Georgij Artem'EvichAndronova Valerija L'VovnaGurskij Georgij ValerianovichSurovaja Anna NikitichnaGrokhovskij Sergej L'Vovich

(73)

Holder

Gosudarstvennoe Uchrezhdenie Nauchno-Issledovatel'Skij Institut Virusologii Im. D.I. Ivanovskogo Rossijskoj Akademii Meditsinskikh NaukUchrezhdenie Rossijskoj Akademii Nauk Institut Molekuljarnoj Biologii Im. V.A. Ehngel'Gardta Ran

NETROPSIN DERIVATIVES HAVING ANTIVIRAL ACTIVITY Russian patent published in 2010 - IPC C07K14/00 C07K5/06 A61K38/05 A61K38/16 A61K31/40 A61P31/12 A61P31/22

Abstract RU 2394838 C2

FIELD: chemistry.

SUBSTANCE: invention relates to medical virology. The essence of the invention lies in demonstration of selective antiviral activity in netropsin derivatives: SARC-NT, Pt-bis-NT and 15Lys-bis-NT. Antiviral activity is studied on the example of anti-herpes viral and anti-orthopox viral activity in SARC-NT. A new effect was discovered in the compounds: Pt-bis-NT and 15Lys-bis-NT - anti-orthopox viral activity.

EFFECT: obtaining compounds which provide highly effective inhibition of infections caused by copox and herpes viruses; Pt-bis-NT and 15Lys-bis-NT provide highly effective inhibition of infection caused by cowpox virus; SARC-NT has considerable anti-orthopox viral activity and moderate anti-herpes viral activity; SARC-NT, Pt-bis-NT and 15Lys-bis-NT have potential for use in preparing new antiviral agents.

2 cl, 4 dwg, 1 tbl, 4 ex

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RU 2 394 838 C2

Authors

Galegov Georgij Artem'Evich

Andronova Valerija L'Vovna

Gurskij Georgij Valerianovich

Surovaja Anna Nikitichna

Grokhovskij Sergej L'Vovich

Dates

2010-07-20—Published

2008-07-08—Filed