3-ETHYLIDENEHYDRAZINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS Russian patent published in 2010 - IPC C07D333/32 C07D231/18 C07D409/12 C07D401/12 C07D409/14 A61K31/381 A61K31/4155 A61K31/4523 A61K31/496 A61P7/04 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (1), their tautomers and pharmaceutically acceptable salts. The disclosed compounds have thromobopoietin receptor agonist properties. In formula (1) , A is a nitrogen atom or CH, when A is a nitrogen atom, B is NR⁹ (where R⁹ is a C_1-10 alkyl group), and when A is CH, B is a sulphur atom, R¹ is a phenyl group (the phenyl group is substituted with one or more substitutes selected from a group consisting of halogen atoms, C_1-10 alkyl groups and C_1-10 alkoxy groups (C_1-10 alkyl groups and C_1-10 alkoxy groups are unsubstituted or substituted with one or more halogen atoms)), L¹ is bond, X is OH, R² is a C_1-10 alkyl group, L² is a bond, L³ is NH, L⁴ is a bond or NH, Y is a sulphur atom, and when L⁴ is a bond, R³ is a piperidinyl group, a piperazinyl group (the piperidinyl group and the piperazinyl group are substituted with substitutes selected from a group containing C_1-10 alkoxycarbonyl groups, carboxyl group, hydroxyl groups, di-C_1-10 alkylaminocarbonyl groups, C_1-10 alkylaminocarbonyl groups and C_1-10 alkyl groups (C_1-10 alkylaminocarbonyl groups and C_1-10 alkyl groups are substituted with a substitute selected from a group containing pyridyl groups, hydroxyl groups and carboxyl groups)), or when L⁴ is NH, R³ is a C_1-10 alkyl group (C_1-10 alkyl group is substituted with a substitute selected from a group containing C_1-10 alkoxy groups, C_1-10 alkoxycarbonyl groups or carboxyl groups).

EFFECT: obtaining a thrombopoietin receptor activator which is a formula (1) compound and a medicinal agent which contains the disclosed compound as an active ingredient.

10 cl, 3 tbl, 47 ex