FIELD: chemical industry.
SUBSTANCE: invention relates to a method for producing (8R)-8,13-cyclo-13,14-seco-5β-pregn-2-en-6,14,20-trione of formula (1), wherein 2,3-O-mesylate of poststerone is irradiated with ultrasound (22 kHz, 20 W) in dimethylformamide solution in the presence of 12 equivalents of sodium iodide and 12 equivalents of zinc for 4 h followed by water treatment of the reaction mixture and isolation of the target product using silica gel column chromatography.
(1).
EFFECT: technical result: method for producing (8R)-8,13-cyclo-13,14-seco-5β-pregn-2-en-6,14,20-trione with high yield is developed.
1 cl, 1 ex
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