FIELD: chemistry.
SUBSTANCE: invention relates to novel crystalline polymorphous forms of the rifaximin antibiotic (INN) known as rifaximin δ and rifaximin ε. The invention also relates to a method for synthesis of such polymorphs, which is realised through hot dissolution of crude rifaximin in ethanol and crystallisation of the product, which is induced by adding water at temperature of approximately 50°C and is carried out for approximately 4-36 hours, with subsequent drying at controlled conditions until attaining given content of water in the end product. Novel polymorphs have properties which enable to control rifaximin absorption when used as an antibiotic. The invention also relates to pharmaceutical compositions containing the novel polymorphous forms of rifaximin.
EFFECT: obtaining novel polymorphous forms of rifaximin.
20 cl, 2 tbl, 3 ex, 2 dwg
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