FIELD: pharmaceutics.
SUBSTANCE: invention relates to a pharmaceutical composition characterized by prolonged antibiotic action in the intestinal lumen, containing a therapeutically effective amount of crystalline rifaximin with water content less than 1.0% with characteristic maxima of diffraction angles 2θ: 5.12°; 5.35°; 7.04°; 8.41°; 8.73°; 12.54°; 13.51°; 14.57°; 17.95°; 19.79°; 20.67°; 21.47°; 22.11°; 23.25° per one weight part of rifaximin microcrystalline cellulose – from 0.6 to 0.8 parts, sodium carboxymethyl starch from 0.035 to 0.045 parts, talc from 0.02 to 0.03 parts, silicon dioxide from 0.015 to 0.02 parts and magnesium stearate from 0.005 to 0.01 parts.
EFFECT: creation of a non-toxic pharmaceutical composition of rifaximin with high physicochemical and pharmacokinetic stability and prolonged action.
1 cl, 2 dwg, 4 tbl, 7 ex
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