AMIDE COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS Russian patent published in 2010 - IPC C07D233/32 C07D231/18 C07D409/12 C07D409/14 C07D403/12 C07D413/14 A61K31/381 A61K31/4155 A61K31/5377 A61K31/4535 A61K31/496 A61P7/04 

FIELD: chemistry.

SUBSTANCE: in formula (1) A is a nitrogen atom or CH; when A is a nitrogen atom, B is NR⁹ (where R⁹ is a C_1-10alkyl group), when A is CH, B is a sulphur atom, R¹ is a phenyl group (where the phenyl group is substituted with one or more substitutes selected from a group consisting of halogen atoms, C_1-10alkyl group and C_1-10alkoxy groups (where C_1-10alkyl groups and C_1-10alkoxy groups are not substituted of substituted with one or more halogen atoms)); L¹ is a bond; X is OH; R² is a C_1-6alkyl group; L² is a bond; L³ is NH; L⁴ is a bond or NH; Y is an oxygen atom or sulphur atom; R³ is a thienyl group (where the thienyl group is substituted with CONR²⁹R³⁰ (where R²⁹ is hydrogen or a C_1-10alkyl group, and R³⁰ is an amino group (where the amino group is not substituted or substituted with a pyridyl group), mono- or di-C_1-10alkylamino group, N-methylpiperzinyl group, piperidine group, morpholine group or C_1-10alkyl group (C_1-10alkyl group is substituted with one or more substitutes selected from a group consisting of a carboxyl group, carbamoyl groups, pyrroldinyl groups, tetrahydrofuryl groups or morpholine groups) or R²⁹ and R³⁰ together denote -(CH₂)_m3-G-(CH₂)_m4- (where G is CR³¹R³² (where R³¹ is a hydrogen atom and R³² is a C_1-10alkylcarbonylamino group or pyrrolidinyl group) and each of m3 and m4 is independently equal to an integer from 0 to 5 provided that m3+m4 equals 3, 4 or 5), or NR²⁹R³⁰ as a whole denotes a piperidine group or pyrrolidinyl group (where the piperidine group or pyrrolidinyl group is substituted with two substitutes independently selected from a group consisting of: hydroxyl groups and C1-10alkoxy groups) or 2-(4-oxopyrridin-1(4H)-yl)acetyl group), phenyl group (where the phenyl group is substituted with one substitute selected from a group consisting of C_1-10alkyl groups, C_1-10alkylcarbonyl groups and C_1-10alkylaminocarbonyl groups, (where C_1-10alkyl group, C_1-10alkylcarbonyl group and C_1-10alkylaminocarbonyl group are substituted with one or two substitutes selected from a group consisting of hydroxyl groups, carboxyl groups and carbamoyl groups)), phenyl group (where the phenyl group is substituted with one C_1-10alkylaminocarbonyl group or one halogen atom), dihydrobenzo[1,4]dioxine group or benzo[1,4]oxazine group. The invention also relates to a medicinal agent containing the disclosed compound as an active ingredient and to a thromopoeitin receptor activator which is a formula (1) compound.

EFFECT: disclosed compounds have thrombopoietin receptor agonist properties.

8 cl, 11 tbl, 128 ex