IMMUNOGENIC COMPOSITION Russian patent published in 2010 - IPC A61K39/85 A61K38/12 A61P31/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention concerns an immunogenic composition containing staphylococcal PNAG of N-acetylation less than 50%, and capsular polysaccharide or oligosaccharide type 8 of Staphylococcus aureus. The composition can additionally contain capsular polysaccharide or oligosaccharide type 5 of S. aureus, capsular polysaccharide or oligosaccharide type I and/or type II, and/or type III of S.epidermidis, and also staphylococcal protein or its fragment which is bound to an extracellular component. Staphylococcal polysaccharide found in the composition can be conjugated with a carrier protein specified from group of tetanus toxoid, diphtheria toxoid, pneumococcal pneumolysin, alpha toxin, CRM197, N influenzae protein D, P.aeruginosa exoprotein A. Also there are described a staphylococcal vaccine, a method for preparing said vaccine, a methods for prevention or treatment of staphylococcal infection with using the vaccine and application of the immunogenic compositions for preparing the vaccine for prevention or treatment of staphylococcal infection.

EFFECT: use of the invention provides an effective immune response on more staphylococci strains, preferentially on strains types 8 and 5 of S aureus and serotypes I, II and III of Sepidermidis.

18 cl, 55 dwg, 8 tbl, 8 ex