USE OF 9-AROYL-8-HYDROXY-6-(2-HYDROXYALKYL)-2-THIOXO-1,3,6-TRIAZASPIRO[4.4]NON-8-ENE-4,7-DIONES AS AGENTS WITH HIGH ANTIMICROBIAL ACTIVITY AGAINST STAPHYLOCOCCUS AUREUS AND CANDIDA ALBICANS Russian patent published in 2024 - IPC C07D487/10 A61K31/4188 A61P31/04 

FIELD: chemistry.

SUBSTANCE: invention relates to use of 9-aroyl-8-hydroxy-6-(2-hydroxyalkyl)-2-thioxo-1,3,6-triazaspiro[4.4]non-8-ene-4,7-diones of general formula below as agents having antimicrobial activity against S. aureus and C. albicans. In the formula R¹ = H, R² = H, Ar =4-BrC₆H₄ (6a); R¹ = CH₃, R² = H, Ar = Ph (6b); R¹ = CH₃, R² = H, Ar = 4-ClC₆H₄ (6c); R¹ = CH₃, R² = H, Ar = 4-BrC₆H₄ (6d); R¹ = CH₃, R² = H, Ar = 4-CH₃C₆H₄ (6e); R¹ = H, R² = Ph, Ar = Ph (6f); R¹ = H, R² = Ph, Ar = 4-ClC₆H₄ (6g); R¹ = CH₃, R² = Ph, Ar = 4-BrC₆H₄ (6h); R¹ = CH₃, R² = Ph, Ar = 4-CH₃C₆H₄ (6i); R¹ = H, R² = Bu, Ar = Ph (6j); R¹ = CH₃, R² = Bu, Ar = 4-BrC₆H₄ (6k).

EFFECT: invention can be used in pharmacology.

1 cl, 1 tbl, 12 ex