FIELD: folic acid bis-amides.
SUBSTANCE: folic acid bis-amides of general formula I with two substituents, each containing 9 boron atoms.
EFFECT: technical result of the invention is the creation of a new group of chemical compounds - folic acid bis -amides containing nido -carborane residues of low toxicity, able to accumulate in tumor cells, which can be used as agents for boron neutron capture therapy of tumor diseases.
1 cl, 2 tbl, 4 ex
BH or B
CH or C
| Title | Year | Author | Number |
|---|---|---|---|
| CARBORANE DERIVATIVES OF 4,4-DIFLUORO-4-BORA-3α,4α-DIASE-s-INDACENE SHOWING ANTI-TUMOR ACTIVITY | 2022 |
|
RU2789401C1 |
| CARBORANYL DERIVATIVES OF FLOURINATED PORPHYRINS AND METAL COMPLEXES THEREOF, HAVING PHOTOSENSITISER PROPERTIES, AND SYNTHESIS METHOD THEREOF | 2008 |
|
RU2402554C2 |
| CARBORANYLPORPHYRINE AND USE THEREOF | 2007 |
|
RU2477161C2 |
| METHOD OF REGIOSELECTIVE SYNTHESIS OF MONOHALOGENDERIVATIVES OF 1,2-, 1,7-, 1,12-DICARBA-CLOSO-DODECARBORANES(12) WITH APPLICATION OF ULTRASOUND ACTIVATION | 2013 |
|
RU2536686C1 |
| METAL-COMPLEX OF CARBORANYLPORPHYRINS ELICITING ANTITUMOR ACTIVITY | 2002 |
|
RU2236411C2 |
| METHOD OF REGIOSELECTIVE SYNTHESIS OF MONOHALOGEN-DERIVATIVES OF 1,2-,1,7-,1,12-DICARBA-CLOSO-DODECABORANES(12) WITH APPLICATION OF COMPLEX ACTIVATION | 2013 |
|
RU2535677C1 |
| METHOD FOR REGIOSELECTIVE SYNTHESIS OF MONOHALOGEN DERIVATIVES OF 1,2-, 1,7-, 1,12-DICARBA-CLOSO-DODECABORANES(12) | 2013 |
|
RU2521592C1 |
| BORON COMPOUNDS EFFECTIVE IN BORON NEUTRON CAPTURE THERAPY | 2006 |
|
RU2423368C2 |
| BORATED DERIVATIVES OF FLUORINATED BACTERIOCHLORINES AND THEIR METAL COMPLEXES WITH ANTITUMOR ACTIVITY | 2015 |
|
RU2615770C1 |
| 4-[(PURIN-6-YL)AMINOPOLYMETHYLENECARBONYL]-DERIVATIVES OF 3,4-DIHYDRO-3-METHYL-7,8-DIFLUORO-2H-[1,4]BENZOXAZINE WITH ANTITUMOR ACTIVITY | 2021 |
|
RU2760305C1 |
