METHOD OF TREATING LOCALLY ADVANCED BREAST CANCER Russian patent published in 2010 - IPC A61B17/00 A61N5/00 A61B18/04 A61K31/513 A61K31/675 A61K31/704 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, oncology, and can be used for treating locally advanced breast cancer. For this purpose, the method starts with chemotherapy. 15-30 minutes later, it is followed with hyperthermia at temperature 41.0-42.0°C on the periphery of a tumour at exposure time 90-60 min, respectively. If observing involution of the tumour more than by 30% by RECIST criteria, radical mastectomy followed by radiation therapy is performed. A less evident involution requires preoperative radiation therapy followed by radical mastectomy.

EFFECT: method allows improving a local therapeutic effect due to the fact that on the periphery of the tumour, total vascular dilatation and blood flow increase are observed that allows for maximum penetration of medicinal agents into the tumour, and in the centre of the tumour, high temperature is generated because of decreased blood flow and therefore heat extraction thereupon by the end of the procedure in the tumour region, blood flow is slowed in vessels and stops almost, the cumulated medicinal agents are kept in the tumour for a long time that allow prolonging the cytotoxic action of chemopreparations on malignant cells.

3 cl, 6 dwg, 2 tbl, 5 ex