FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesis of methyl ether of 5-acetyl-2-furan carboxylic acid, which is used as a starting compound in synthesis of pharmaceutical preparations. The method for synthesis of methyl ether of 5-acetylfuran-2-carboxylic acid of formula 
is characterised by that 2-acetylfuran reacts with CCl4 and methanol in an autoclave under argon in the presence of a catalyst selected from a group comprising ferrocene (Fe(C5H5)2), tris(2,4-pentanedionato)iron (Fe(acac)3), iron bromide (FeBr2) in molar ratio [catalyst]:[2-acetylfuran]:[CCl4]:[methanol]=1:100:100-200:200-2000, at temperature 120°C for 6-9 hours. Output of methyl ether of 5-acetyl-2-furan carboxylic acid can be 87-95% depending on the nature of the catalyst used.
EFFECT: high yield.
1 tbl, 19 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 5-ACETYLPYRROLE-2-CARBOXYLIC ACID METHYL ETHER SYNTHESIS METHOD | 2008 |
|
RU2404162C2 |
| METHOD PRODUCING METHYL ETHER OF 2-BENZO[b]FURAN-CARBOXYLIC ACID | 2010 |
|
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|
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|
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|
RU2404166C1 |
| PRODUCTION METHOD FOR METHYL ETHERS OF 2-THIOPHEN CARBONIC ACID AND ITS DERIVATIVES | 2007 |
|
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|
RU2402535C2 |
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| METHOD FOR PRODUCING ALKYL ETHERS OF METOXYBENZOIC ACIDS | 2016 |
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RU2640206C1 |
