1-DICHLOROMETHYLISOQUINOLINE SYNTHESIS METHOD Russian patent published in 2010 - IPC C07D217/04 

Abstract RU 2402535 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method for synthesis of 1-dichloromethylisoquinoline which is involves reaction of isoquinoline with CCl4 and MeOH in the presence of a catalyst based on iron compounds, preferably iron (III) acetyl acetone (Fe(acac)3) or ferrocene (Fe[C5H5]2) at 145-155°C for 4-6 hours in molar ratio [catalyst] : [C9H7N] : [CCl4] : [methanol] equal to 1-5 : 100 : 700-1000 : 800-1100.

EFFECT: high output and low cost of 1-dichloromethylisoquinoline, as well as simplification of the technology as a whole.

1 cl, 1 tbl, 1 ex

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RU 2 402 535 C2

Authors

Dzhemilev Usein Memetovich

Khusnutdinov Ravil Ismagilovich

Bajguzina Al'Fija Ruslanovna

Mukminov Rinat Rifkhatovich

Dates

2010-10-27Published

2008-10-06Filed