FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesis of 1-dichloromethylisoquinoline which is involves reaction of isoquinoline with CCl4 and MeOH in the presence of a catalyst based on iron compounds, preferably iron (III) acetyl acetone (Fe(acac)3) or ferrocene (Fe[C5H5]2) at 145-155°C for 4-6 hours in molar ratio [catalyst] : [C9H7N] : [CCl4] : [methanol] equal to 1-5 : 100 : 700-1000 : 800-1100.
EFFECT: high output and low cost of 1-dichloromethylisoquinoline, as well as simplification of the technology as a whole.
1 cl, 1 tbl, 1 ex
Title | Year | Author | Number |
---|---|---|---|
5-ACETYLPYRROLE-2-CARBOXYLIC ACID METHYL ETHER SYNTHESIS METHOD | 2008 |
|
RU2404162C2 |
METHOD OF OBTAINING METHYL ESTER OF 2-BENZO[b]FURANCARBOXYLIC ACID | 2010 |
|
RU2467004C2 |
METHOD FOR SYNTHESIS OF METHYL ETHER OF 5-ACETYLFURAN-2-CARBOXYLIC ACID | 2008 |
|
RU2404173C2 |
1-ACETYLISOQUINOLINE SYNTHESIS METHOD | 2009 |
|
RU2404166C1 |
METHOD PRODUCING METHYL ETHER OF 2-BENZO[b]FURAN-CARBOXYLIC ACID | 2010 |
|
RU2455299C2 |
METHOD OF PRODUCING DIMETHYL ETHER OF 2,5-THIOPHENE DICARBOXYLIC ACID FROM THIOPHENE | 2008 |
|
RU2404176C2 |
METHOD OF PRODUCING 1-CHLOROADAMANTANE | 2011 |
|
RU2486169C2 |
METHOD OF PRODUCING 2-PHENYL-3-ALKYLQUINOLINES | 2014 |
|
RU2565787C1 |
PRODUCTION METHOD FOR METHYL ETHERS OF 2-THIOPHEN CARBONIC ACID AND ITS DERIVATIVES | 2007 |
|
RU2359968C2 |
METHOD FOR PREPARING LEVULINIC ACID ESTERS | 2006 |
|
RU2319690C1 |
Authors
Dates
2010-10-27—Published
2008-10-06—Filed