METHOD PRODUCING METHYL ETHER OF 2-BENZO[b]FURAN-CARBOXYLIC ACID Russian patent published in 2012 - IPC C07D307/83 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and particularly to a method of producing methyl ether of 2-benzo[b]furan-carboxylic acid, which is used as a starting compound in synthesis of pharmaceutical agents. The method involves reaction of benzo[b]furan with carbon tetrabromide and methanol in the presence of an iron-containing catalyst selected from ferrocene (Fe(C₅H₅)₂), iron (III) acetyl acetonate or iron (II) bromide and a radical initiator - H₂O₂. The reaction is carried out at temperature 90-110°C for 8-10 hours in an argon atmosphere, molar ratio of components [catalyst]:[H₂O₂]:[benzo[b]furan]:[CBr₄]:[methanol]=1:5:100:200:1000-1100.

EFFECT: high output of methyl ether of 2-benzo[b]furan-carboxylic acid, absence of aggressive oxidants, simple technique owing to low power consumption.

1 cl, 3 ex, 1 tbl