METHOD FOR SYNTHESIS OF ETHYLENEDIAMINE DERIVATIVES HAVING HALOGENATED CARBAMATE GROUP AND ACYL GROUP, AND INTERMEDIATE SUBSTANCES FOR SYNTHESIS OF DERIVATIVES Russian patent published in 2010 - IPC C07C269/06 C07C269/04 C07C271/20 C07C271/22 C07D207/09 C07D207/16 C07D231/14 C07D307/85 C07D403/12

Abstract RU 2404963 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method for synthesis of ethylenediamine derivatives (4), having a halogenated carbamate group and an acyl group, involving catalytic hydrogenation of aminonitrile with a halogen-substituted carbamate group in the presence of an acid and then acylation of the formed amino derivative. The initial aminonitrile may be obtained with high output by reacting an amino acid amide with a halogen-substituted carbamating agent in the presence of water and then reacting the formed amide, which has a halogen-substituted carbamate group, with a reducing agent such as a Wilsmeyer reagent.

EFFECT: high yield.

22 cl, 45 ex

Similar patents RU2404963C2

Title	Year	Author	Number
NOVEL ANTICONVULSIVE SUBSTITUTED SULFAMATE DERIVATIVES	2003	Abdel'-Magid Akhmed Marianoff Sintija Mermehn Stiven Sordzhi Kirk Villani Frehnk Kordik Cheril P. Rejtts Allen B. Marianoff Brjus Ehliot	RU2328502C2
NOVEL DERIVATIVES OF PHENYLALANINE	2001	Makino Singo Okuzumi Tatsuja Josimura Tosikhiko Satake Juko Suzuki Nobujasu Izava Khirojuki Sagi Kazujuki Tiba Akira Nakanisi Eidzi Murata Masakhiro Tsudzi Takasi	RU2286340C2
XANTHINE-PHOSPHODIESTERASE V INHIBITORS, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITION, USE, AND TREATMENT METHOD	2001	Chakalamannil Sehmjuehl Vehng Juguang Bojl Krejg D. Stehmford Ehndrju V.	RU2302420C9
COMPLEXES	2015	Colacot, Thomas Chow, Ruishan Jon Deangelis, Andrew	RU2682680C2
METHOD OF PRODUCING FLUORINE-CONTAINING ACYLACETIC ACID DERIVATIVE, METHOD OF PRODUCING FLUORINE-CONTAINING PYRAZOLECARBOXYLIC ACID ESTER DERIVATIVE AND METHOD OF PRODUCING FLUORINE-CONTAINING PYRAZOLECARBOXYLIC ACID DERIVATIVE	2009	Umehtani Khidehki Kakimoto Takehsi Aoki Jodzi	RU2456275C2
TRIAZOLE DERIVATIVES	2007	Ono Naoja Takajama Tetsuo Siozava Fumijasu Katakai Khironori Jabuuti Tetsuja Ota Tomomi Jagi Makoto Sato Masakazu	RU2409570C2
PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS	2001	Dehvis Robert Bebbington Dehvid Negtel Ronal'D Vehnnamehjker Marion Li Pehn Forester Kornelija Pirs Ehlbert Kehj Dehvid	RU2340611C2
HETEROARYLCARBOXYLIC ACID ESTER DERIVATIVES	2013	Kosiba Takakhiro Tokumasu Munetaka Itimaru Tajsuke Osumi Kodzi Nakagava Tadakie Yamada Tatsukhiro Matsumoto Kajo Suzuki Tamotsu	RU2664544C2
METHOD OF PRODUCING THIOPHENE DERIVATIVE AND INTERMEDIATE PRODUCT THEREOF	2009	Janagikhara Kazufumi Umezava Singo Mijadzi Katsuaki	RU2495877C2
BICYCLIC PYRROLE DERIVATIVES	2005	Nakakhira Khirojuki Kimura Khidenori Khotigai Khitosi	RU2382786C2

RU 2 404 963 C2

Authors

Umetani Khideki

Kokhno Tosijuki

Dates

2010-11-27—Published

2007-03-27—Filed