FIELD: chemistry.
SUBSTANCE: described are novel derivatives of genera formula (1) 
(where A denotes an oxygen or sulphur atom, -CH2- or -NH- group; R1 denotes C1-6alkyl group, possibly substituted ; R1A denotes a hydrogen atom or a C1-6 alkyl group; or these two radicals together with a carbon atom to which they are bonded form a cyclic C3-6 alkyl group; R2 denotes a C1-6 alkyl group or a C3-6 cycloalkyl group; R3 denotes an aryl group or a heteroaryl group, which can be substituted; R4 denotes a hydrogen atom; R5 denotes C1-6 alkyl group, aryl or heteroaryl group, which can be substituted), a pharmaceutical composition containing said derivatives and intermediate compounds. Said compounds (1) can inhibit bonding between SIP and its receptor Edg-1 (SIP1).
EFFECT: possibility of use in medicine.
18 cl, 2 tbl, 28 ex
| Title | Year | Author | Number |
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| SPHINGOSINE-1-PHOSPHATE BINDING INHIBITOR | 2007 |
|
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|
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| DERIVATIVES OF DIARYLALKANES CONTAINING ALICYCLIC GROUP AND ELICITING ANTAGONISM WITH RESPECT TO SEROTONIN-2-RECEPTORS AND/OR INHIBITORY ACTIVITY WITH RESPECT TO SQUALENE SYNTHASE, COMPOSITION FOR TREATMENT AND PROPHYLAXIS OF CARDIOVASCULAR DISEASES | 1997 |
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RU2232761C2 |
