FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to pharmacology. Composition of vaccine stabiliser contains at least one amino acid in amount from 0.025 to 100 g/l, at least one sugar in amount from 2.5 to 50 g/l and at least one polyamine in amount from 0.025 to 25 g/l, where all compounds are chemically specified, thus, being free of serum, protein, animal compounds, polymer, in which only average molecular weight or average length of lateral chains are available, from protein lysate, extract of hydrolysate or peptide mixture, characterised by the fact that polyamine represents at least one selected from group made of ethylene diamine, cadaverine, putrescine, spermidine and spermine. Invention also relates to composition of vaccine containing specified composition of stabiliser and biological molecule and/or microorganism; to method for making of pharmaceutical composition providing for mixing of specified composition of stabiliser with biological molecule and/or microorganism; to application of specified composition of stabiliser and vaccines prepared by this method.
EFFECT: improved stabilising properties of stabiliser and stability of vaccine.
30 cl, 13 tbl, 1 ex
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