FIELD: medicine, pharmaceutics.
SUBSTANCE: presented inventions refer to a lyophilised composition for inducing an immune response to flavivirus, compositions for preparing the above lyophilised composition, and a method for preparing the lyophilised composition. The characterised lyophilised composition contains an effective amount of live attenuated flavivirus, one or more stabilising agents, one or more buffer components, lactose and amorphous mannitol, which is prepared by lyophilising mixture containing an effective amount of live attenuated flavivirus, one or more stabilising agents, one or more buffer components, lactose and mannitol; flavivirus can be chimeric flavivirus. Preparing the above lyophilised composition involves freezing the components and drying them thereafter.
EFFECT: inventions enable preparing the transportation and storage stable compositions containing flavivirus.
31 cl, 13 dwg, 10 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| VACCINE COMPOSITIONS AGAINST HUMAN PAPILLOMA VIRUS (HPV), CONTAINING ALUMINIUM ADJUVANT, AND METHODS OF PRODUCTION THEREOF | 2012 |
|
RU2610174C2 |
| INACTIVATED CHIMERIC VACCINES AND RELATED METHODS OF APPLICATION | 2006 |
|
RU2436591C2 |
| COMPOSITION APPLICABLE AS ROTAVIRUS VACCINE AND METHOD FOR PRODUCING IT | 2010 |
|
RU2553331C2 |
| COMPOSITION OF NEUREGULIN PREPARATION | 2014 |
|
RU2738158C2 |
| IMMUNOGENIC COMPOSITIONS COMPRISING SILICIFIED VIRUS AND METHODS OF USE | 2014 |
|
RU2676083C2 |
| METHOD AND AGENT ACTIVATING IRF-3 FOR TREATING AND PREVENTING DISEASES CAUSED BY (+) RNA CONTAINING VIRUSES | 2012 |
|
RU2518314C2 |
| STABLE AQUEOUS COMPOSITIONS OF PROTEIN MIA/CD-RAP | 2011 |
|
RU2588658C2 |
| CHIMERIC FLAVIVIRAL VACCINES | 1998 |
|
RU2209082C2 |
| LYOPHILISED ANTIBACTERIAL PROTEIN COMPOSITIONS | 2017 |
|
RU2708393C1 |
| THROMBIN SOLUTION AND METHODS FOR USE THEREOF | 2013 |
|
RU2670956C9 |
