FLUORENE DERIVATIVES, HAVING ANTIPROLIFERATIVE ACTIVITY, CELL DIFFERENTIATION MODULATORS, METHOD OF SLOWING DOWN TUMOUR CELL PROLIFERATION, METHOD OF INDUCING DIFFERENTIATION IN MOUSE MELANOMA CELLS Russian patent published in 2011 - IPC C07D221/16 C07C13/567 C07D471/00 A61K31/4353 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to substituted fluorene compounds and specifically to a compound of formula where R₁ denotes a NH₂-group or a Br atom; R₂ denotes hydrogen or halogen; R3 is selected from the following group: oxygen, aminoalkyl group =N-alkyl, where alkyl C₁-C₁₂ (having normal or branched structure), aminoaryl group=N-aryl, where aryl: phenyl, naphthyl, aminoheteroaryl group=N-heteroaryl, where heteroaryl: pyridine, quinoline, phenylamine. The invention also relates to a method of slowing down proliferation of tumour cells, involving addition of an acceptable amount of an active compound of formula (1) into the medium, and to a method of inducing differentiation in mouse melanoma cells B16-F10.

EFFECT: novel compounds which can be active agents which inhibit tumour proliferation and activate differentiation in mouse melanoma cells B16-F10 are obtained and described.

11 cl, 8 tbl, 11 dwg