XANTHINE DERIVATIVES, HAVING ANTIPROLIFERATIVE ACTIVITY, CELL DIFFERENTIATION MODULATORS, METHOD OF SLOWING DOWN TUMOUR CELL PROLIFERATION, METHOD OF INDUCING DIFFERENTIATION IN CELLS Russian patent published in 2011 - IPC C07D473/00 C07D473/40 C07D473/08 C07D473/12 C07D473/10 A61P35/00 

FIELD: chemistry.

SUBSTANCE: disclosed agent is a xanthine derivative of formula 1

, where R₁ denotes CH₃, R₂ denotes CH₃; R₃ denotes halogens: F,Cl, Br, I; R₄ denotes hydrogen; R₁ denotes CH₃, R₂ denotes CH₃; R₃ denotes hydrogen, halogens: F, Cl, Br, I; R₄ denotes CH₂COOH; R₁ denotes hydrogen, R₂ denotes CH₃; R₃ denotes halogens: F, Cl, Br, I; R₄ denotes CH₃. The preferred compounds of the said agent are 8-chlorotheophylline, 8-bromotheophylline and theophylline-7-acetate. The invention also relates to a method of slowing down proliferation of tumour cells and a method of inducing differentiation in mouse melanoma B16-F10 cells. Each of the methods involves addition of an effective amount of the said agent in an effective amount, preferably in amount of 1 mM.

EFFECT: improved properties of the derivatives.

8 cl, 4 tbl, 12 dwg